It's easy to figure out how your camera needs to be oriented if you do a little research before you go out. Look up the object in a desktop planetarium program or a star atlas. Most will have an outline of the object itself and you can see how to frame it.
Most desktop planetarium programs will let you input the size of your DSLR sensor, and the focal length of your scope so that it can calculate your field of view, and then plot an overlay on top of a map with the deepsky object. That way you will know exactly how to frame it so it will look the best.